View source for 9p33


==Crystal structure of the Bromo domain 1 in human Bromodomain Containing Protein 4 with a compound==
<StructureSection load='9p33' size='340' side='right'caption='[[9p33]], [[Resolution|resolution]] 1.01&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9p33]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9P33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9P33 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.01&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C7T:(3S,4S)-4-{(5M)-5-{2-[2-methyl-5-(propan-2-yl)phenoxy]pyrimidin-4-yl}-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl}pyrrolidin-3-ol'>A1C7T</scene>, <scene name='pdbligand=A1C7U:(3S,4R)-4-{(5M)-5-{2-[2-methyl-5-(propan-2-yl)phenoxy]pyrimidin-4-yl}-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl}pyrrolidin-3-ol'>A1C7U</scene>, <scene name='pdbligand=A1CGX:(3~{R},4~{R})-4-[5-[2-(2-methyl-5-propan-2-yl-phenoxy)pyrimidin-4-yl]-4-[4-(trifluoromethyl)phenyl]imidazol-1-yl]pyrrolidin-3-ol'>A1CGX</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9p33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9p33 OCA], [https://pdbe.org/9p33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9p33 RCSB], [https://www.ebi.ac.uk/pdbsum/9p33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9p33 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> 
== Function ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Aihara H]]
[[Category: Pomerantz WCK]]
[[Category: Scholtz C]]
[[Category: Shi K]]
[[Category: Vail N]]