View source for 9p3l


==Structure of ANDV dimer of tetramer at conformation III==
<StructureSection load='9p3l' size='340' side='right'caption='[[9p3l]], [[Resolution|resolution]] 3.37&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9p3l]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Andes_orthohantavirus Andes orthohantavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9P3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9P3L FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.37&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9p3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9p3l OCA], [https://pdbe.org/9p3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9p3l RCSB], [https://www.ebi.ac.uk/pdbsum/9p3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9p3l ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GP_ANDV GP_ANDV] Forms homotetramers with glycoprotein C at the surface of the virion (By similarity). Attaches the virion to host cell receptors including integrin ITGAV/ITGB3 (By similarity). This attachment induces virion internalization possibly through clathrin-dependent endocytosis and dynamin-independent macropinocytosis (Probable). Mediates the assembly and budding of infectious virus particles through its interaction with the nucleocapsid protein and the viral genome (By similarity). May dysregulate normal immune and endothelial cell responses through an ITAM motif (By similarity). Translocates to mitochondria, binds to host TUFM and recruits MAP1LC3B (By similarity). These interactions induce mitochondrial autophagy and therefore destruction of host MAVS leading to inhibition of type I interferon (IFN) responses (By similarity). Concomitant breakdown of glycoprotein N is apparently prevented by the nucleoprotein that may inhibit Gn-stimulated autophagosome-lysosome fusion (By similarity). Interacts with the viral genomic RNA (By similarity). Inhibits the host RIG-I/TBK1 pathway by disrupting the formation of TBK1-TRAF3 complexes and downstream signaling responses required for IFN-beta transcription (PubMed:16973572, PubMed:24390324).[UniProtKB:P08668][UniProtKB:P27312]<ref>PMID:16973572</ref> <ref>PMID:24390324</ref>   Forms homotetramers with glycoprotein N at the surface of the virion. Attaches the virion to host cell receptors including integrin ITGAV/ITGB3. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (By similarity). Class II fusion protein that promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion (PubMed:27414047, PubMed:31180319).[UniProtKB:P08668]<ref>PMID:27414047</ref> <ref>PMID:31180319</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Andes orthohantavirus]]
[[Category: Large Structures]]
[[Category: Luqiang G]]
[[Category: McLellan JS]]