View source for 9pbt


==ARP of SWI/SNF of PIC-Med-SWI/SNF-Nucleosome==
<StructureSection load='9pbt' size='340' side='right'caption='[[9pbt]], [[Resolution|resolution]] 5.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9pbt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PBT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9pbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9pbt OCA], [https://pdbe.org/9pbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9pbt RCSB], [https://www.ebi.ac.uk/pdbsum/9pbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9pbt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RT102_YEAST RT102_YEAST] Probable component of the chromatin structure-remodeling complex (RSC) which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. Probable component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Chen D-H]]
[[Category: Nagai S]]
[[Category: Yang C]]