View source for 9pfp


==Structure of POU2F3 POU domains bound to coactivator OCA-T1 and DNA==
<StructureSection load='9pfp' size='340' side='right'caption='[[9pfp]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9pfp]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PFP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BO3:BORIC+ACID'>BO3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9pfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9pfp OCA], [https://pdbe.org/9pfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9pfp RCSB], [https://www.ebi.ac.uk/pdbsum/9pfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9pfp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PO2F3_HUMAN PO2F3_HUMAN] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and regulates cell type-specific differentiation pathways. Involved in the regulation of keratinocytes differentiation (PubMed:11329378). The POU2F3-POU2AF2/POU2AF3 complex drives the expression of tuft-cell-specific genes, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (PubMed:35576971).<ref>PMID:11329378</ref> <ref>PMID:35576971</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Alpsoy A]]
[[Category: Ipsaro JJ]]
[[Category: Joshua-Tor L]]
[[Category: Vakoc CR]]