View source for 9plp


==Crystal structure of netrin-1 in complex with anti-netrin-1 Fab (NP137 Fab)==
<StructureSection load='9plp' size='340' side='right'caption='[[9plp]], [[Resolution|resolution]] 4.99&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9plp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PLP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.99&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9plp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9plp OCA], [https://pdbe.org/9plp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9plp RCSB], [https://www.ebi.ac.uk/pdbsum/9plp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9plp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NET1_CHICK NET1_CHICK] Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors.
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</StructureSection>
[[Category: Gallus gallus]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Bailey-Elkin BA]]
[[Category: Rafiei F]]
[[Category: Stetefeld J]]