View source for 9pum


==Human respirovirus 3 hemagglutinin-neuraminidase dimer in complex with VHH A2R3-60==
<StructureSection load='9pum' size='340' side='right'caption='[[9pum]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9pum]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_respirovirus_3 Human respirovirus 3] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PUM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9pum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9pum OCA], [https://pdbe.org/9pum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9pum RCSB], [https://www.ebi.ac.uk/pdbsum/9pum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9pum ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HN_PI3HA HN_PI3HA] Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).  Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
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</StructureSection>
[[Category: Human respirovirus 3]]
[[Category: Large Structures]]
[[Category: Vicugna pacos]]
[[Category: McLellan JS]]
[[Category: Zhou L]]