View source for 9pxb


==Hamster Scap/Insig-2 complex with cholesterol and bound Fab4G10==
<StructureSection load='9pxb' size='340' side='right'caption='[[9pxb]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9pxb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PXB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9pxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9pxb OCA], [https://pdbe.org/9pxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9pxb RCSB], [https://www.ebi.ac.uk/pdbsum/9pxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9pxb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SCAP_CRIGR SCAP_CRIGR] Escort protein required for cholesterol as well as lipid homeostasis (PubMed:10497220, PubMed:12482938, PubMed:15728349, PubMed:15899885, PubMed:17428919, PubMed:8898195). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:10497220, PubMed:12482938, PubMed:15728349, PubMed:15899885, PubMed:17428919, PubMed:27068746, PubMed:8898195). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (PubMed:12482938, PubMed:15728349, PubMed:15899885, PubMed:27068746). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (PubMed:15728349, PubMed:15899885, PubMed:17428919, PubMed:27068746). Binds cholesterol via its SSD domain (PubMed:15260976, PubMed:27068746).<ref>PMID:10497220</ref> <ref>PMID:12482938</ref> <ref>PMID:15260976</ref> <ref>PMID:15728349</ref> <ref>PMID:15899885</ref> <ref>PMID:17428919</ref> <ref>PMID:27068746</ref> <ref>PMID:8898195</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Cricetulus griseus]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Bai X]]
[[Category: Kober DL]]
[[Category: Radhakrishnan A]]
[[Category: Rosenbaum DM]]
[[Category: Williams BC]]