View source for 9q24


==Structure of the Measles virus Hemagglutinin ectodomain in complex with two neutralizing antibodies 1C08 and 4D08==
<StructureSection load='9q24' size='340' side='right'caption='[[9q24]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9q24]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Measles_morbillivirus Measles morbillivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Q24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Q24 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9q24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9q24 OCA], [https://pdbe.org/9q24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9q24 RCSB], [https://www.ebi.ac.uk/pdbsum/9q24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9q24 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HEMA_MEASC HEMA_MEASC] Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis (By similarity).
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Measles virus (MeV), a highly transmissible paramyxovirus, can cause severe complications and death, particularly in infants and young children. How and where human antibodies target and neutralize MeV remain unclear. Here, we report a panel of human monoclonal antibodies (mAbs) specific for MeV hemagglutinin (H) and fusion (F) surface proteins, derived from the memory B cells of a Measles-Mumps-Rubella (MMR) vaccinee. We mapped four and five major epitope clusters on H and F, respectively, and structurally characterized representative mAbs from each epitope cluster. MAbs against both H and F offer broad, potent, picomolar-level neutralization and substantially reduce viral loads in vivo when delivered before or after viral exposure. High-resolution cryo-electron microscopy of mAb complexes with H and F reveal highly conserved contact sites of the most protective antibodies. Characterization of these fully human mAbs provides avenues for prophylactic or therapeutic intervention against re-emerging MeV.

Human neutralizing antibodies targeting the measles virus hemagglutinin and fusion surface proteins.,Acciani M, Zyla D, Niemeyer G, Harkins S, Parekh D, Pawlack E, Lacarbonara D, Kansara D, Ackerman ME, Niewiesk S, Porotto M, Hastie KM, Saphire EO Cell Host Microbe. 2026 Jun 10;34(6):1067-1081.e12. doi: , 10.1016/j.chom.2026.04.010. Epub 2026 May 7. PMID:42102820<ref>PMID:42102820</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 9q24" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Measles morbillivirus]]
[[Category: Acciani M]]
[[Category: Niemeyer G]]
[[Category: Saphire EO]]
[[Category: Zyla D]]