View source for 9qhn


==Cryo-EM structure of mouse TRPM3 alpha 2 in APO state==
<StructureSection load='9qhn' size='340' side='right'caption='[[9qhn]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9qhn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QHN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PH:1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE'>3PH</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qhn OCA], [https://pdbe.org/9qhn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qhn RCSB], [https://www.ebi.ac.uk/pdbsum/9qhn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qhn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRPM3_MOUSE TRPM3_MOUSE] Constitutively active, non-selective divalent cation-conducting channel that is permeable to Ca(2+), Mn(2+), and Mg(2+), with a high permeability for Ca(2+) (PubMed:15824111, PubMed:20401728, PubMed:32780479). However, can be enhanced by increasing temperature and by ligands, including the endogenous neurosteroid pregnenolone sulfate and sphingosine-1 and suppressed by intracellular Mg(2+) (PubMed:20401728, PubMed:21555074). Implicated in a variety of cellular processes, including insulin/peptide secretion, vascular constriction and dilation, noxious heat sensing, inflammatory and spontaneous pain sensitivity (PubMed:21555074, PubMed:30853321, PubMed:33478988). In neurons of the dorsal root ganglia, functions as thermosensitive channel for the detection of noxious heat and spontaneous pain (PubMed:21555074, PubMed:33478988). Suggested to function as an ionotropic steroid receptor in beta-cell, indeed pregnenolone sulfate leads to Ca(2+) influx and enhanced insulin secretion (PubMed:18978782). Mediates Zn(2+) uptake into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion (PubMed:20401728). Forms heteromultimeric ion channels with TRPM1 which are permeable for Ca(2+) and Zn(2+) ions (By similarity). Exists as multiple splice variants which differ significantly in their biophysical properties (PubMed:15824111, PubMed:22961981).[UniProtKB:Q9HCF6]<ref>PMID:15824111</ref> <ref>PMID:18978782</ref> <ref>PMID:20401728</ref> <ref>PMID:21555074</ref> <ref>PMID:22961981</ref> <ref>PMID:30853321</ref> <ref>PMID:32780479</ref> <ref>PMID:33478988</ref>   Displays strongly reduced permeability for divalent cations and high selectivity toward monovalent cations.<ref>PMID:15824111</ref>   No channel activity.<ref>PMID:22961981</ref>   No channel activity.<ref>PMID:22961981</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Brunner JD]]
[[Category: Schenck S]]
[[Category: Shkumatov AV]]