View source for 9qlm


==Solution structure of the TAF3-PHD bound to a H3K4me3Q5ser histone tail peptide with a serotonylated glutamine==
<StructureSection load='9qlm' size='340' side='right'caption='[[9qlm]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9qlm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QLM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene>, <scene name='pdbligand=SRO:SEROTONIN'>SRO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qlm OCA], [https://pdbe.org/9qlm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qlm RCSB], [https://www.ebi.ac.uk/pdbsum/9qlm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qlm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TAF3_MOUSE TAF3_MOUSE] Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.<ref>PMID:17704303</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Bonvin AMJJ]]
[[Category: Gielingh H]]
[[Category: Honorato RV]]
[[Category: Jongkees S]]
[[Category: Liu M]]
[[Category: Pulido-Cortes L]]
[[Category: Soares LR]]
[[Category: Thijssen V]]
[[Category: Timmers HThM]]
[[Category: Yoshisada R]]
[[Category: Van Ingen H]]