View source for 9qo8


==Inward-open structure of human GABA transporter 3 bound to selective inhibitor SR-THAP==
<StructureSection load='9qo8' size='340' side='right'caption='[[9qo8]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9qo8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QO8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1I87:(2~{S})-2-oxidanyl-2-[(2~{R})-1-[(~{E})-4,4,4-tris(4-methoxyphenyl)but-2-enyl]pyrrolidin-2-yl]ethanoic+acid'>A1I87</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qo8 OCA], [https://pdbe.org/9qo8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qo8 RCSB], [https://www.ebi.ac.uk/pdbsum/9qo8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qo8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/S6A11_HUMAN S6A11_HUMAN] Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:7874447). Can also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine (By similarity).[UniProtKB:P31650]<ref>PMID:7874447</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bavo F]]
[[Category: Frolund B]]
[[Category: Jensen MH]]
[[Category: Mortensen JS]]
[[Category: Pape T]]
[[Category: Pedersen APS]]
[[Category: Shahsavar A]]
[[Category: Storm JP]]
[[Category: Wellendorph P]]