View source for 9qq5


==Mini-bacterioferritin from Candidatus Methanoperedens species BLZ2 in a partially oxidized state==
<StructureSection load='9qq5' size='340' side='right'caption='[[9qq5]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9qq5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candidatus_Methanoperedens_sp._BLZ2 Candidatus Methanoperedens sp. BLZ2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QQ5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FEC:1,3,5,8-TETRAMETHYL-PORPHINE-2,4,6,7-TETRAPROPIONIC+ACID+FERROUS+COMPLEX'>FEC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qq5 OCA], [https://pdbe.org/9qq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qq5 RCSB], [https://www.ebi.ac.uk/pdbsum/9qq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qq5 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Ferritins are ubiquitous among life forms, as they are essential for iron homeostasis. Here, we unveiled a novel member of the ferritin family, baptised mini-bacterioferritin. The characterised mini-bacterioferritin was isolated from a microbial enrichment dominated by the methanotrophic archaeon 'Candidatus Methanoperedens carboxydivorans'. Its atomic resolution crystal structure reveals a 12-mer assembly with a diiron ferroxidase centre located within a four-helix bundle. Redox-cycling experiments on protein crystals reveal a shift in iron position at the active site, which follows the established ferritin catalytic cycle. The 12-mer sphere-like structure harboured six Fe-coproporphyrin III ligands, positioned at the interdimeric interface, a characteristic previously only found in 24-mer bacterioferritins. Phylogenetics, together with structure predictions of closely related proteins, revealed that mini-bacterioferritins form a distinct clade within the ferritin family that might conserve ancestral traits. Future research will need to investigate the physiological roles of these enzymes, which were unsuspectingly widely distributed among prokaryotes.

Mini-bacterioferritins: structural insight into a ferritin-like protein from the anaerobic methane-oxidising archaeon Candidatus Methanoperedens carboxydivorans.,Wissink M, Engilberge S, Leao P, Jansen RS, Jetten MSM, Belhamri M, Lemaire ON, Royant A, Welte CU, Wagner T Commun Biol. 2026 Mar 21. doi: 10.1038/s42003-026-09796-4. PMID:41865068<ref>PMID:41865068</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 9qq5" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Candidatus Methanoperedens sp. BLZ2]]
[[Category: Large Structures]]
[[Category: Wagner T]]
[[Category: Wissink M]]