View source for 9qsh


==Cryo-EM structure of the MMM ubiquitin ligase complex with nanobody 992 (Composite map)==
<StructureSection load='9qsh' size='340' side='right'caption='[[9qsh]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9qsh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QSH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JAX:(1~{S},2~{S},4~{S},5~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-16-methoxy-5,7,9,13-tetramethyl-spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2-oxane]'>A1JAX</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qsh OCA], [https://pdbe.org/9qsh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qsh RCSB], [https://www.ebi.ac.uk/pdbsum/9qsh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qsh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MGRN1_HUMAN MGRN1_HUMAN] E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H (PubMed:17229889, PubMed:19703557). Plays a role in the regulation of endosome-to-lysosome trafficking (PubMed:17229889). Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production (PubMed:19737927). Does not inhibit ADRB2-signaling (PubMed:19737927). Does not promote MC1R ubiquitination (PubMed:19737927). Acts also as a negative regulator of hedgehog signaling (By similarity).[UniProtKB:Q9D074]<ref>PMID:17229889</ref> <ref>PMID:19703557</ref> <ref>PMID:19737927</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Bazan F]]
[[Category: Carrique L]]
[[Category: Gao L]]
[[Category: Hedger G]]
[[Category: Kong JH]]
[[Category: Lartey D]]
[[Category: Latorraca NR]]
[[Category: Marqusee S]]
[[Category: Milenkovic L]]
[[Category: Nocka LM]]
[[Category: Parashara P]]
[[Category: Pardon E]]
[[Category: Pusapati GV]]
[[Category: Rohatgi R]]
[[Category: Rouse SL]]
[[Category: Sarkar P]]
[[Category: Siebold C]]
[[Category: Steyaert J]]
[[Category: Williams C]]