View source for 9qwq


==Human vault protein - committed conformation==
<StructureSection load='9qwq' size='340' side='right'caption='[[9qwq]], [[Resolution|resolution]] 4.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9qwq]] is a 78 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QWQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.45&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qwq OCA], [https://pdbe.org/9qwq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qwq RCSB], [https://www.ebi.ac.uk/pdbsum/9qwq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qwq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MVP_HUMAN MVP_HUMAN] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.<ref>PMID:15133037</ref> <ref>PMID:16441665</ref> <ref>PMID:16418217</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Aupic J]]
[[Category: Cassetta A]]
[[Category: Durand A]]
[[Category: Lapenta F]]
[[Category: Marechal N]]