View source for 9r78


==Human Adenovirus D 10 Capsid Structure==
<StructureSection load='9r78' size='340' side='right'caption='[[9r78]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9r78]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_D10 Human adenovirus D10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9R78 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9R78 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9r78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9r78 OCA], [https://pdbe.org/9r78 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9r78 RCSB], [https://www.ebi.ac.uk/pdbsum/9r78 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9r78 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/K7ZRR7_9ADEN K7ZRR7_9ADEN] Endosome lysis protein: Structural component of the virion that provides increased stability to the particle shell through its interaction with the core-capsid bridging protein and the hexon-linking protein VIII. Fibers shedding during virus entry into host cell allows the endosome lysis protein to be exposed as a membrane-lytic peptide. Exhibits pH-independent membrane fragmentation activity and probably mediates viral rapid escape from host endosome via organellar membrane lysis. It is not clear if it then remains partially associated with the capsid and involved in the intracellular microtubule-dependent transport of capsid to the nucleus, or if it is lost during endosomal penetration.[HAMAP-Rule:MF_04048]  Pre-protein VI: During virus assembly, promotes hexon trimers nuclear import through nuclear pore complexes via an importin alpha/beta-dependent mechanism. By analogy to herpesviruses capsid assembly, might act as a chaperone to promote the formation of the icosahedral capsid.[HAMAP-Rule:MF_04048]  Protease cofactor: Cofactor that activates the viral protease. Binds to viral protease in a 1:1 ratio.[HAMAP-Rule:MF_04048]
__TOC__
</StructureSection>
[[Category: Human adenovirus D10]]
[[Category: Large Structures]]
[[Category: Baker AT]]
[[Category: Bates EA]]
[[Category: Bhella D]]
[[Category: Morris E]]
[[Category: Mundy RM]]
[[Category: Parker AL]]
[[Category: Rizkallah PJ]]
[[Category: Waraich K]]
[[Category: Young MT]]
[[Category: Da Fonseca P]]