View source for 9rbl


==Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide MKV558==
<StructureSection load='9rbl' size='340' side='right'caption='[[9rbl]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9rbl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RBL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1H92:3-(cyclooctylamino)-5-ethoxy-2,6-bis(fluoranyl)-4-(3-oxidanylpropylsulfonyl)benzenesulfonamide'>A1H92</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rbl OCA], [https://pdbe.org/9rbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rbl RCSB], [https://www.ebi.ac.uk/pdbsum/9rbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rbl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAH9_HUMAN CAH9_HUMAN] Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.<ref>PMID:18703501</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Leitans J]]
[[Category: Tars K]]