View source for 9rca


==Solution NMR structure of the lipoyl domain of the E2 subunit in the human alpha-ketoglutarate dehydrogenase complex==
<StructureSection load='9rca' size='340' side='right'caption='[[9rca]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9rca]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RCA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR,  models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rca OCA], [https://pdbe.org/9rca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rca RCSB], [https://www.ebi.ac.uk/pdbsum/9rca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rca ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ODO2_HUMAN ODO2_HUMAN] Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711).[UniProtKB:Q9N0F1]<ref>PMID:29211711</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ambrus A]]
[[Category: Batta G]]
[[Category: Czajlik A]]