View source for 9rf6


==SUDV VP40 in complex with LL093==
<StructureSection load='9rf6' size='340' side='right'caption='[[9rf6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9rf6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sudan_ebolavirus Sudan ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RF6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JFC:2-oxidanyl-5-[(phenylmethyl)carbamoylamino]benzoic+acid'>A1JFC</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rf6 OCA], [https://pdbe.org/9rf6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rf6 RCSB], [https://www.ebi.ac.uk/pdbsum/9rf6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rf6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VP40_EBOSU VP40_EBOSU] Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. May facilitate virus budding by interacting with the nucleocapsid and the plasma membrane. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. The hexamer form seems to be involved in budding. The octamer form binds RNA, and may play a role in genome replication (By similarity).
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</StructureSection>
[[Category: Large Structures]]
[[Category: Sudan ebolavirus]]
[[Category: Becker S]]
[[Category: Diederich W]]
[[Category: Laube L]]
[[Category: Sandner A]]
[[Category: Werner A-D]]