View source for 9rhm


==Phospho-MCM double hexamer bound to Sld3-Sld7-Cdc45 on ARS1 DNA==
<StructureSection load='9rhm' size='340' side='right'caption='[[9rhm]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9rhm]] is a 17 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RHM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rhm OCA], [https://pdbe.org/9rhm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rhm RCSB], [https://www.ebi.ac.uk/pdbsum/9rhm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rhm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SLD7_YEAST SLD7_YEAST] Required for the proper function of SLD3 at the initiation of DNA replication. Binds to SLD3 and reduces its affinity for CDC45, a component of the replication fork. Required for mitochondrial morphology.<ref>PMID:16135527</ref> <ref>PMID:21487389</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Butryn A]]
[[Category: Costa A]]
[[Category: Couves EC]]
[[Category: Puehringer T]]