View source for 9rit


==Co-crystal of broadly neutralizing biparatopic VHH in complex with cardiotoxin (P01468) Naja pallida==
<StructureSection load='9rit' size='340' side='right'caption='[[9rit]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9rit]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_pallida Naja pallida] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RIT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rit OCA], [https://pdbe.org/9rit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rit RCSB], [https://www.ebi.ac.uk/pdbsum/9rit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rit ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/3SA1_NAJPA 3SA1_NAJPA] Basic protein that binds to cell membrane and depolarizes cardiomyocytes. This cytotoxin also possesses lytic activity on many other cells, including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation. Inhibits protein kinases C. It binds to the integrin alpha-V/beta-3 with a moderate affinity.[UniProtKB:P01443]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Naja pallida]]
[[Category: Vicugna pacos]]
[[Category: Burlet NJ]]
[[Category: Laustsen AH]]
[[Category: Morth JP]]