View source for 9rjc


==Apo Structure of the Human Signal Peptidase==
<StructureSection load='9rjc' size='340' side='right'caption='[[9rjc]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9rjc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RJC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rjc OCA], [https://pdbe.org/9rjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rjc RCSB], [https://www.ebi.ac.uk/pdbsum/9rjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rjc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SC11A_HUMAN SC11A_HUMAN] Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (PubMed:34388369).<ref>PMID:34388369</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Abhay K]]
[[Category: Forster GF]]
[[Category: Koh FA]]
[[Category: Liaci AM]]
[[Category: Skalidis I]]
[[Category: Vismpas D]]