View source for 9rkz


==CryoEM structure of human 20S proteasome in complex with proteasome inhibitor CP-17==
<StructureSection load='9rkz' size='340' side='right'caption='[[9rkz]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9rkz]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RKZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JHK:~{N}-[(2~{S})-3-(1~{H}-indol-3-yl)-1-[[(2~{S})-3-(1~{H}-indol-3-yl)-1-[[(2~{S},3~{R},4~{S})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]amino]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-propan-2-yl]hexanamide'>A1JHK</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rkz OCA], [https://pdbe.org/9rkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rkz RCSB], [https://www.ebi.ac.uk/pdbsum/9rkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rkz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PSA6_HUMAN PSA6_HUMAN] The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Benova V]]
[[Category: Boura E]]
[[Category: Fajtova P]]
[[Category: Silhan J]]
[[Category: Suelzen H]]