View source for 9rlb


==Crystal structure of FGD2 from Mycobacterium tuberculosis in complex with TEW and Para isopropylaniline (fragment a6-11)==
<StructureSection load='9rlb' size='340' side='right'caption='[[9rlb]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9rlb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RLB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ISO:PARA-ISOPROPYLANILINE'>ISO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rlb OCA], [https://pdbe.org/9rlb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rlb RCSB], [https://www.ebi.ac.uk/pdbsum/9rlb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rlb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FHMAD_MYCTU FHMAD_MYCTU] Catalyzes the coenzyme F420-dependent oxidation of hydroxymycolic acids (H-MAs) to ketomycolic acids (K-MAs), a lipid class making up the mycobacterial pseudo-outer membrane and over one-third of the dry weight of M.tuberculosis (PubMed:24349169). Does not exhibit F420-dependent glucose-6-phosphate dehydrogenase (FGD) activity (PubMed:23110042).<ref>PMID:23110042</ref> <ref>PMID:24349169</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Aderemi A]]
[[Category: Leys D]]
[[Category: Snee M]]