View source for 9rqm


==GT-C O-Mannosyltransferase TMEM260 co-purified with natural donor and in complex with acceptor peptide==
<StructureSection load='9rqm' size='340' side='right'caption='[[9rqm]], [[Resolution|resolution]] 3.06&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9rqm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RQM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.06&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IZY:[(2~{S},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]+[(3~{S},6~{Z},10~{E},14~{E})-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraenyl]+hydrogen+phosphate'>IZY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rqm OCA], [https://pdbe.org/9rqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rqm RCSB], [https://www.ebi.ac.uk/pdbsum/9rqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rqm ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TM260_HUMAN TM260_HUMAN] Structural heart defects-renal anomalies syndrome. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/TM260_HUMAN TM260_HUMAN] O-mannosyl-transferase that transfers mannosyl residues to the hydroxyl group of serine or threonine residues of proteins (PubMed:37186866). Specifically glycosylates the IPT/TIG domain of target proteins, such as MET and MST1R/RON (PubMed:37186866). TMEM260-mediated O-mannosylated residues are composed of single mannose glycans that are not elongated or modified (PubMed:37186866).<ref>PMID:37186866</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cifuente JO]]
[[Category: Ubarretxena-Belandia I]]