View source for 9rtw


==Mammalian AP3 complex on tubular membranes (AP3 centered)==
<StructureSection load='9rtw' size='340' side='right'caption='[[9rtw]], [[Resolution|resolution]] 7.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9rtw]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RTW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rtw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rtw OCA], [https://pdbe.org/9rtw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rtw RCSB], [https://www.ebi.ac.uk/pdbsum/9rtw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rtw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A2I3SW12_PANTR A0A2I3SW12_PANTR] Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.[ARBA:ARBA00023570]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Pan troglodytes]]
[[Category: Rattus norvegicus]]
[[Category: Briggs JAG]]
[[Category: Kaufman JGG]]
[[Category: Owen DJ]]
[[Category: Tagiltsev G]]