View source for 9rve


==Structure of human 1918 influenza A polymerase heterotrimer in complex with 1918 NEP.==
<StructureSection load='9rve' size='340' side='right'caption='[[9rve]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9rve]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Brevig_Mission/1/1918(H1N1)) Influenza A virus (A/Brevig Mission/1/1918(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RVE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.53&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rve OCA], [https://pdbe.org/9rve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rve RCSB], [https://www.ebi.ac.uk/pdbsum/9rve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rve ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PA_I18A0 PA_I18A0] Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.[HAMAP-Rule:MF_04063]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Carrique L]]
[[Category: Chen K]]
[[Category: Fodor M]]
[[Category: Grimes JM]]
[[Category: Rep A]]
[[Category: Wang F]]