View source for 9rzf


==Structure of in-vivo formed alpha-synuclein fibrils purified from a M83+/- mouse brain injected with recombinant 1B fibrils==
<StructureSection load='9rzf' size='340' side='right'caption='[[9rzf]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9rzf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RZF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rzf OCA], [https://pdbe.org/9rzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rzf RCSB], [https://www.ebi.ac.uk/pdbsum/9rzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rzf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SYUA_MOUSE SYUA_MOUSE] Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282, PubMed:25246573). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).[UniProtKB:P37840]<ref>PMID:20798282</ref> <ref>PMID:25246573</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Arotcarena M]]
[[Category: Baron T]]
[[Category: Berbon M]]
[[Category: Bezard E]]
[[Category: Bousset L]]
[[Category: Burger D]]
[[Category: Canron M]]
[[Category: De Giorgi F]]
[[Category: De Nuccio F]]
[[Category: Feuillie C]]
[[Category: Ichas F]]
[[Category: Kashyrina M]]
[[Category: Laferriere F]]
[[Category: Lewis AJ]]
[[Category: Lofrumento DD]]
[[Category: Loquet A]]
[[Category: Meissner WG]]
[[Category: Mohammed I]]
[[Category: Nilsson KPR]]
[[Category: Poujol C]]
[[Category: Retailleau A]]
[[Category: Stahlberg H]]
[[Category: Verchere J]]
[[Category: De La Seigliere H]]
[[Category: Van den Heuvel L]]