View source for 9s8i


==Crystal Structure of UDP-N-acetylmuramate-L-alanine ligase (MurC) from Pseudomonas aeruginosa in complex with compound OSA_001176 (WYH78)==
<StructureSection load='9s8i' size='340' side='right'caption='[[9s8i]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9s8i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9S8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9S8I FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=WIR:(1~{R},2~{S})-1-[[4-[(5-~{tert}-butyl-1-methyl-pyrazol-3-yl)amino]-1~{H}-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-2,3-dihydro-1~{H}-inden-2-ol'>WIR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9s8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9s8i OCA], [https://pdbe.org/9s8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9s8i RCSB], [https://www.ebi.ac.uk/pdbsum/9s8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9s8i ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MURC_PSEAE MURC_PSEAE] Cell wall formation.[HAMAP-Rule:MF_00046]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Diaz-Saez L]]
[[Category: Dowson CG]]
[[Category: Lloyd AJ]]
[[Category: Todd MH]]
[[Category: Wang Y]]