View source for 9seh


==mechanosensitive channel MscS from Francisella tularensis, mutant F108A==
<StructureSection load='9seh' size='340' side='right'caption='[[9seh]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9seh]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis Francisella tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SEH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9seh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9seh OCA], [https://pdbe.org/9seh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9seh RCSB], [https://www.ebi.ac.uk/pdbsum/9seh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9seh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0B3VCY4_FRATU A0A0B3VCY4_FRATU] Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.[RuleBase:RU369025]
__TOC__
</StructureSection>
[[Category: Francisella tularensis]]
[[Category: Large Structures]]
[[Category: Bottcher B]]
[[Category: Flegler VJ]]
[[Category: Hemmelmann N]]
[[Category: Hove TT]]
[[Category: Rasmussen A]]
[[Category: Rasmussen T]]