View source for 9sfw


==Structure of Pex8 in complex with peroxisomal receptor Pex5==
<StructureSection load='9sfw' size='340' side='right'caption='[[9sfw]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9sfw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Komagataella_pastoris Komagataella pastoris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SFW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9sfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9sfw OCA], [https://pdbe.org/9sfw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9sfw RCSB], [https://www.ebi.ac.uk/pdbsum/9sfw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9sfw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PEX8_PICPA PEX8_PICPA] Essential component of the machinery required for the import of both PTS1 and PTS2 (and perhaps all) peroxisomal matrix proteins (PubMed:7738036). Binding of PEX8 to the N-terminus of PEX5 cargo receptor induces a conformational change of the TPR domains and decrease their binding affinity to cargo, facilitating the release of the PTS1 proteins within the peroxisome (PubMed:23902771).<ref>PMID:23902771</ref> <ref>PMID:7738036</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Komagataella pastoris]]
[[Category: Large Structures]]
[[Category: Chojnowski G]]
[[Category: Ekal L]]
[[Category: Mullapudi E]]
[[Category: Wilmanns M]]