View source for 9shd


==Structure of vaccinia virus A26 (residues 1-397) in complex with Fab 10M2146==
<StructureSection load='9shd' size='340' side='right'caption='[[9shd]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9shd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SHD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SHD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9shd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9shd OCA], [https://pdbe.org/9shd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9shd RCSB], [https://www.ebi.ac.uk/pdbsum/9shd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9shd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PG153_VACCW PG153_VACCW] Envelop protein that mediates acid-dependent endocytosis into host cells (PubMed:20538855). Plays an important role in endocytic entry of the virus by acting as an acid-sensitive membrane fusion suppressor (PubMed:22278246, PubMed:31220181). Low pH in host endosomes triggers conformational changes to allow de-repression of viral fusion complex activity and membrane fusion within vesicles (PubMed:31220181). Plays also a role in bridging the mature virion with structural protein OPG152.<ref>PMID:20538855</ref> <ref>PMID:22278246</ref> <ref>PMID:31220181</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Vaccinia virus]]
[[Category: Battini L]]
[[Category: Guardado-Calvo P]]