View source for 9sks


==Cryo-EM structure of H. neapolitanus CsoSCA in oxidizing conditions, dimer, major state, active conformation==
<StructureSection load='9sks' size='340' side='right'caption='[[9sks]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9sks]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Halothiobacillus_neapolitanus_c2 Halothiobacillus neapolitanus c2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SKS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9sks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9sks OCA], [https://pdbe.org/9sks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9sks RCSB], [https://www.ebi.ac.uk/pdbsum/9sks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9sks ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/CSOCA_HALNC CSOCA_HALNC] Reversible hydration of carbon dioxide (PubMed:14729686, PubMed:17012396, PubMed:18258595). Essential for chemolithotrophic carbon dioxide fixation, supplies CO(2) to RuBisCO (ribulose bisphosphate carboxylase, cbbL-cbbS) in the carboxysome (Probable) (PubMed:18258595). There are estimated to be 40 CsoSCA dimers per carboxysome (Ref.5).<ref>PMID:14729686</ref> <ref>PMID:17012396</ref> <ref>PMID:18258595</ref> <ref>PMID:18258595</ref> <ref>PMID:14729686</ref>   Unlike beta-carboxysomes, alpha-carboxysomes (Cb) can form without cargo protein. CsoS2 is essential for Cb formation and is also capable of targeting foreign proteins to the Cb. The Cb shell assembles with the aid of CsoS2; CsoS1A, CsoS1B and CsoS1C form the majority of the shell while CsoS4A and CsoS4B form vertices. CsoS1D forms pseudohexamers that probably control metabolite flux into and out of the shell.<ref>PMID:33116131</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Halothiobacillus neapolitanus c2]]
[[Category: Large Structures]]
[[Category: Blikstad C]]
[[Category: Gaullier G]]
[[Category: Vogiatzi N]]