View source for 9smn


==BRCA1-A complex bound to K63-polyUbATA - open form StateC StateP==
<StructureSection load='9smn' size='340' side='right'caption='[[9smn]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9smn]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SMN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JPL:(3~{R})-4-azanyl-3-sulfanyl-butanoic+acid'>A1JPL</scene>, <scene name='pdbligand=DAB:2,4-DIAMINOBUTYRIC+ACID'>DAB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9smn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9smn OCA], [https://pdbe.org/9smn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9smn RCSB], [https://www.ebi.ac.uk/pdbsum/9smn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9smn ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ABRX1_HUMAN ABRX1_HUMAN] Disease susceptibility is associated with variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/ABRX1_HUMAN ABRX1_HUMAN] Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.<ref>PMID:17525340</ref> <ref>PMID:17643121</ref> <ref>PMID:17643122</ref> <ref>PMID:18077395</ref> <ref>PMID:19261748</ref> <ref>PMID:22357538</ref> <ref>PMID:26778126</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Murachelli AG]]
[[Category: Sixma TK]]