View source for 9snl


==transcription factor ELF3==
<StructureSection load='9snl' size='340' side='right'caption='[[9snl]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9snl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SNL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.701&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9snl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9snl OCA], [https://pdbe.org/9snl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9snl RCSB], [https://www.ebi.ac.uk/pdbsum/9snl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9snl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ELF3_HUMAN ELF3_HUMAN] Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).<ref>PMID:9234700</ref> <ref>PMID:9336459</ref> <ref>PMID:9129154</ref> <ref>PMID:9395241</ref> <ref>PMID:9417054</ref> <ref>PMID:10391676</ref> <ref>PMID:10644990</ref> <ref>PMID:10773884</ref> <ref>PMID:11036073</ref> <ref>PMID:11313868</ref> <ref>PMID:12713734</ref> <ref>PMID:12414801</ref> <ref>PMID:12624109</ref> <ref>PMID:12682075</ref> <ref>PMID:14715662</ref> <ref>PMID:15075319</ref> <ref>PMID:15169914</ref> <ref>PMID:14767472</ref> <ref>PMID:15794755</ref> <ref>PMID:16307850</ref> <ref>PMID:17060315</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Morgunova E]]
[[Category: Popov A]]
[[Category: Taipale J]]
[[Category: Yin Y]]