View source for 9sos


==Tissue Inhibitor of Matrix Metalloproteinase-1 (TIMP-1)==
<StructureSection load='9sos' size='340' side='right'caption='[[9sos]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9sos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SOS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9sos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9sos OCA], [https://pdbe.org/9sos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9sos RCSB], [https://www.ebi.ac.uk/pdbsum/9sos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9sos ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TIMP1_HUMAN TIMP1_HUMAN] Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Shemy A]]
[[Category: Voet A]]