View source for 9t66


==Complex linking two repeat units of a cytoplasmic lattice filament==
<StructureSection load='9t66' size='340' side='right'caption='[[9t66]], [[Resolution|resolution]] 5.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9t66]] is a 36 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9T66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9T66 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9t66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9t66 OCA], [https://pdbe.org/9t66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9t66 RCSB], [https://www.ebi.ac.uk/pdbsum/9t66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9t66 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PADI6_MOUSE PADI6_MOUSE] Structural constituent of cytoplasmic lattices, which plays a key role in early embryonic development (PubMed:16137333, PubMed:17587491, PubMed:18599511, PubMed:27929740, PubMed:37922900). Cytoplasmic lattices consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (PubMed:37922900). They are required to store maternal proteins critical for embryonic development, such as ribosomal proteins and proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation (PubMed:18599511, PubMed:37922900, PubMed:38453481). In contrast to other members of the family, does not show protein-arginine deiminase activity due to its inability to bind Ca(2+) (By similarity).[UniProtKB:Q6TGC4]<ref>PMID:16137333</ref> <ref>PMID:17587491</ref> <ref>PMID:18599511</ref> <ref>PMID:27929740</ref> <ref>PMID:37922900</ref> <ref>PMID:38453481</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Carter AP]]
[[Category: Harasimov K]]
[[Category: Singh K]]