View source for 9t68


==Composite structure of the repeat unit of cytoplasmic lattice filament==
<StructureSection load='9t68' size='340' side='right'caption='[[9t68]], [[Resolution|resolution]] 8.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9t68]] is a 96 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9T68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9T68 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9t68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9t68 OCA], [https://pdbe.org/9t68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9t68 RCSB], [https://www.ebi.ac.uk/pdbsum/9t68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9t68 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KHDC3_MOUSE KHDC3_MOUSE] Required for maintenance of euploidy during cleavage-stage embryogenesis. Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function. Capable of binding RNA.<ref>PMID:19376971</ref> <ref>PMID:22276159</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Carter AP]]
[[Category: Harasimov K]]
[[Category: Singh K]]