View source for 9tfv


==Cryo-EM structure of the inward rectifying potassium channel 7.1 (Kir7.1)==
<StructureSection load='9tfv' size='340' side='right'caption='[[9tfv]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9tfv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9TFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9TFV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9tfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9tfv OCA], [https://pdbe.org/9tfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9tfv RCSB], [https://www.ebi.ac.uk/pdbsum/9tfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9tfv ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/KCJ13_HUMAN KCJ13_HUMAN] Leber congenital amaurosis;Snowflake vitreoretinal degeneration. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/KCJ13_HUMAN KCJ13_HUMAN] Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.<ref>PMID:9620703</ref> <ref>PMID:9738472</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Faust B]]
[[Category: Nasrallah C]]
[[Category: O'Malley N]]
[[Category: Wallace BA]]