View source for 9tho


==Crystal structure of the adduct formed upon reaction of [V(IV)O(acetylacetonate)2] with human serum transferrin with Fe(III) bound at the C-lobe only==
<StructureSection load='9tho' size='340' side='right'caption='[[9tho]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9tho]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9THO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9THO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JJT:bis(oxidanyl)-oxidanylidene-(oxidanyl(oxidanylidene)vanadio)oxy-vanadium'>A1JJT</scene>, <scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9tho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9tho OCA], [https://pdbe.org/9tho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9tho RCSB], [https://www.ebi.ac.uk/pdbsum/9tho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9tho ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref> 
== Function ==
[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The interaction of vanadium compounds of pharmaceutical interest with metal-transport proteins like human serum transferrin (hTF) is poorly understood. Direct structural evidence identifying vanadium binding sites on hTF is still lacking. Here, the X-ray structure of the adduct formed when the potential drug [V(IV)O(acac)(2)], with acac = acetylacetonato, reacts with human serum transferrin with Fe(3+) bound at the C-lobe only (Fe(C)-hTF) has been solved and compared with new structures of Fe(C)-hTF used as controls. Structural analysis revealed the presence of a [V(V)(2)O(6)](2-) anion that can be described as a divanadate(V) anion, [V(V)(2)O(7)](4-), that has one oxygen replaced by the phenolate oxygen of Tyr188. The two vanadium centers adopt tetrahedral geometry, consistent with V(V) behavior. The binding does not alter the overall conformation of Fe(C)-hTF that retains the open conformation of the N-lobe and the closed conformation of the C-lobe, remaining able to be recognized by the transferrin receptor.

First crystal structure of an adduct formed upon reaction of a vanadium compound with human serum transferrin.,Banneville AS, Lucignano R, Paolillo M, Cuomo V, Chino M, Ferraro G, Picone D, Garribba E, Cornaciu-Hoffmann I, Pica A, Merlino A Commun Chem. 2026 Jan 16. doi: 10.1038/s42004-026-01891-1. PMID:41545537<ref>PMID:41545537</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 9tho" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Banneville AS]]
[[Category: Cornaciu I]]
[[Category: Ferraro G]]
[[Category: Merlino A]]
[[Category: Paolillo M]]
[[Category: Pica A]]