View source for 9tiu


==cryo-EM structure of wild-type MscL from Escherichia coli in MSP nanodisc==
<StructureSection load='9tiu' size='340' side='right'caption='[[9tiu]], [[Resolution|resolution]] 3.68&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9tiu]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9TIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9TIU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.68&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9tiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9tiu OCA], [https://pdbe.org/9tiu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9tiu RCSB], [https://www.ebi.ac.uk/pdbsum/9tiu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9tiu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MSCL_ECOLI MSCL_ECOLI] Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Forms a nonselective ion channel with a conductance of about 4 nanosiemens. Participates in the regulation of osmotic pressure changes within the cell. Opens at a pressure just below that which would cause cell disruption and death. The force required to trigger channel opening depends on the membrane lipids composition.<ref>PMID:10202137</ref> <ref>PMID:23416054</ref> <ref>PMID:23875651</ref> <ref>PMID:7511799</ref> <ref>PMID:9632260</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Lange A]]
[[Category: Sprink T]]
[[Category: Xiao T]]