View source for 9tuf


==Crystal Structure of isolated Death Domain of human p53-induced protein PIDD (778-873) with Thr788Asp phosphomimetic mutation.==
<StructureSection load='9tuf' size='340' side='right'caption='[[9tuf]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9tuf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9TUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9TUF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9tuf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9tuf OCA], [https://pdbe.org/9tuf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9tuf RCSB], [https://www.ebi.ac.uk/pdbsum/9tuf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9tuf ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PIDD1_HUMAN PIDD1_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/PIDD1_HUMAN PIDD1_HUMAN] Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264, PubMed:15073321, PubMed:16360037, PubMed:17159900). Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis (PubMed:15073321, PubMed:17159900). Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (PubMed:16360037, PubMed:17159900).<ref>PMID:10973264</ref> <ref>PMID:15073321</ref> <ref>PMID:16360037</ref> <ref>PMID:17159900</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Baker PJ]]
[[Category: Benavent Bellver P]]
[[Category: Sayers JR]]
[[Category: Thompson R]]
[[Category: Zafred D]]