View source for 9u51


==Cryo-EM structure of Mycobacterium tuberculosis MmpL5 in complex with AcpM==
<StructureSection load='9u51' size='340' side='right'caption='[[9u51]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9u51]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv] and [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9U51 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9U51 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HH:O-[(S)-HYDROXY{[(3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-({3-OXO-3-[(2-SULFANYLETHYL)AMINO]PROPYL}AMINO)BUTYL]OXY}PHOSPHORYL]-L-SERINE'>4HH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9u51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9u51 OCA], [https://pdbe.org/9u51 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9u51 RCSB], [https://www.ebi.ac.uk/pdbsum/9u51 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9u51 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MMPL5_MYCTU MMPL5_MYCTU] Part of an export system, which is required for biosynthesis and secretion of siderophores.<ref>PMID:23431276</ref>   Overexpression of the system confers non-target based resistance to azoles, clofazimine and bedaquiline, via an efflux mechanism.<ref>PMID:18851927</ref> <ref>PMID:24590481</ref> <ref>PMID:25010492</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Mycolicibacterium smegmatis MC2 155]]
[[Category: Gao F]]
[[Category: Li D]]
[[Category: Ma X]]
[[Category: Zhang X]]