View source for 9uf8


==The cryo-EM structure of 26S proteasome-Midnolin complex in the MA state==
<StructureSection load='9uf8' size='340' side='right'caption='[[9uf8]], [[Resolution|resolution]] 4.32&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9uf8]] is a 19 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UF8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.32&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9uf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9uf8 OCA], [https://pdbe.org/9uf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9uf8 RCSB], [https://www.ebi.ac.uk/pdbsum/9uf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9uf8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PSB6_HUMAN PSB6_HUMAN] The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the peptidyl glutamyl-like activity. May catalyze basal processing of intracellular antigens.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Wang HY]]
[[Category: Wei CC]]
[[Category: Xu WQ]]