View source for 9uji


==Crystal structure of the BTB domain mouse Keap1 in complex with CDDO-Im==
<StructureSection load='9uji' size='340' side='right'caption='[[9uji]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9uji]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UJI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.435&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SXJ:(13ALPHA,18ALPHA)-2-CYANO-3-HYDROXY-12-OXOOLEANA-2,9(11)-DIEN-28-OIC+ACID'>SXJ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9uji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9uji OCA], [https://pdbe.org/9uji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9uji RCSB], [https://www.ebi.ac.uk/pdbsum/9uji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9uji ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Iso T]]
[[Category: Mizushima T]]
[[Category: Suzuki T]]
[[Category: Takagi K]]
[[Category: Yamamoto M]]