View source for 9ulo


==Cryo-EM structure of Human Mre11-Nbs1 complex==
<StructureSection load='9ulo' size='340' side='right'caption='[[9ulo]], [[Resolution|resolution]] 3.91&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ulo]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ULO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ULO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.91&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ulo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ulo OCA], [https://pdbe.org/9ulo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ulo RCSB], [https://www.ebi.ac.uk/pdbsum/9ulo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ulo ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MRE11_HUMAN MRE11_HUMAN] Hereditary breast and ovarian cancer syndrome;Ataxia-telangiectasia-like disorder. The disease is caused by mutations affecting the gene represented in this entry.  Defects in MRE11A can be a cause of nephronophthisis-related ciliopathies (NPHP-RC), a group of recessive diseases that affect kidney, retina and brain. A homozygous truncating mutation MRE11A has been found in patients with cerebellar vermis hypoplasia, ataxia and dysarthria.
== Function ==
[https://www.uniprot.org/uniprot/MRE11_HUMAN MRE11_HUMAN] Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Sun Y]]
[[Category: Ying S]]