View source for 9uob


==Plant-TaNNS==
<StructureSection load='9uob' size='340' side='right'caption='[[9uob]], [[Resolution|resolution]] 3.33&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9uob]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Triticum_aestivum Triticum aestivum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UOB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.33&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9uob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9uob OCA], [https://pdbe.org/9uob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9uob RCSB], [https://www.ebi.ac.uk/pdbsum/9uob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9uob ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A9R1FL93_WHEAT A0A9R1FL93_WHEAT] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The recognition of plant-derived immunogenic peptides, known as phytocytokines (PCKs), by cell surface receptors triggers immune signaling pathways that bolster basal plant defense against pathogens. However, little is known about the molecular mechanisms that underlie PCK-mediated immune regulation in wheat. In this study, we identified a wheat PCK, delta-like PCK (DEP), that robustly activates immune responses and confers multi-pathogen resistance. DEP is perceived by the leucine-rich repeat (LRR) receptor kinases (RKs) DEP RECEPTOR 1 (DEPR1) and SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE 2 (SERK2) and triggers DEPR1- and SERK2-dependent immune signaling. Cryogenic electron microscopy structural analysis revealed that DEP2 binds to the extracellular LRR domain of DEPR1 and recruits SERK2 through a disulfide-bond-stabilized loop to promote DEPR1-SERK2 heterodimerization. Furthermore, we showed that the DEP2-DEPR1-SERK2 module confers wheat resistance to Xanthomonas translucens, Fusarium graminearum, and Fusarium pseudograminearum. We also demonstrated that this module enhances wheat resistance to X. translucens by antagonizing abscisic acid signaling. Collectively, our study reveals a novel PCK-mediated immune signaling pathway and suggests a promising strategy for engineering multi-pathogen resistance in wheat.

Recognition of a phytocytokine by the DEPR1-SERK2 receptor complex confers multi-pathogen resistance in wheat.,Wang L, Zhao J, Yin C, Li H, Xiao Y, Du C, Lu Z, Zhang Y, Jia F, Hao J, Yan J, Zhang Y, Li J, Ding X, Han Z, Cui H, Chai J, Deng X, Chi C, Hou S Mol Plant. 2025 Dec 1;18(12):1999-2017. doi: 10.1016/j.molp.2025.10.005. Epub , 2025 Oct 11. PMID:41076557<ref>PMID:41076557</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 9uob" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Triticum aestivum]]
[[Category: Chi C]]
[[Category: Hou S]]
[[Category: Wang L]]
[[Category: Yin C]]
[[Category: Zhao J]]