View source for 9usv


==Two interacting D13 trimers at mode II interface in Twister assembly==
<StructureSection load='9usv' size='340' side='right'caption='[[9usv]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9usv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9USV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9USV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9usv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9usv OCA], [https://pdbe.org/9usv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9usv RCSB], [https://www.ebi.ac.uk/pdbsum/9usv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9usv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PG125_VACCA PG125_VACCA] Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of OPG158 N-terminus.[UniProtKB:P68440]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Vaccinia virus]]
[[Category: Jang YT]]
[[Category: Kim SM]]