View source for 9usw


==Two interacting D13 trimers at mode III interface in Twister assembly==
<StructureSection load='9usw' size='340' side='right'caption='[[9usw]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9usw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9USW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9USW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9usw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9usw OCA], [https://pdbe.org/9usw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9usw RCSB], [https://www.ebi.ac.uk/pdbsum/9usw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9usw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PG125_VACCW PG125_VACCW] Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of OPG158 N-terminus.<ref>PMID:19570860</ref> <ref>PMID:35361762</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Vaccinia virus]]
[[Category: Jang YT]]
[[Category: Kim SM]]