View source for 9usz


==Cryo-EM structure of A17(1-16) peptide-bound D13 trimer from vaccinia virus==
<StructureSection load='9usz' size='340' side='right'caption='[[9usz]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9usz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9USZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9USZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9usz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9usz OCA], [https://pdbe.org/9usz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9usz RCSB], [https://www.ebi.ac.uk/pdbsum/9usz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9usz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PG125_VACCW PG125_VACCW] Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of OPG158 N-terminus.<ref>PMID:19570860</ref> <ref>PMID:35361762</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Vaccinia virus]]
[[Category: Hyun JK]]
[[Category: Jang YT]]
[[Category: Jeong HS]]
[[Category: Jo DG]]
[[Category: Kang ES]]
[[Category: Kim SM]]
[[Category: Kim YH]]
[[Category: Lee SN]]
[[Category: Ryu BH]]
[[Category: Sul JH]]