View source for 9uwd


==Cryo-EM structure of inactive-DP1==
<StructureSection load='9uwd' size='340' side='right'caption='[[9uwd]], [[Resolution|resolution]] 3.41&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9uwd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UWD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.41&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9uwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9uwd OCA], [https://pdbe.org/9uwd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9uwd RCSB], [https://www.ebi.ac.uk/pdbsum/9uwd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9uwd ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PD2R_HUMAN PD2R_HUMAN] Disease susceptibility is associated with variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/PD2R_HUMAN PD2R_HUMAN] Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).[UniProtKB:P70263][UniProtKB:Q9R261]
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Wu C]]
[[Category: Xu HE]]
[[Category: Xu J]]
[[Category: Xu Y]]